Deep inside a cell spreads a maze of folded membranes called the endoplasmic reticulum, or ER for short. When ribosomes dot its outer surface, scientists call it rough ER. Those tiny protein factories build new chains right into the ER lumen, the space inside the membrane tunnels. Rough ER is the cell's production and packaging line, turning genetic recipes into proteins that will travel to membranes, organelles, or out of the cell entirely.
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Rough ER gets its bumpy look from thousands of ribosomes stuck to the outside. Under an electron microscope those dots make the membrane look rough, which is exactly how it got its name.